Neurons and the DHA Principle

Neurons and the DHA Principle

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Studies with bacteria and other systems suggest that the omega-3 fatty acid DHA confers great benefits to neurons in maximizing both speed of neural impulses and energy efficiency. Unfortunately, studies also show that DHAa€™s ease of oxidation damages membrane integrity. Exploring this duality, Neurons and the DHA Principle proposes a new model for the causes of neurodegeneration, in which DHA-enriched membranes of neurons become dysfunctional and energetically wasteful, triggering the premature death of neurons. The challenge of this book is to digest how DHA acts as an essential building block of neurons while also conspiring for their assassination during aging. As the book reviews the extraordinary properties of DHA in life forms from deep-sea bacteria to human neurons, it asks: Is there a trade-off between speed and efficiency of brain function enabled by DHA versus longevity or life span? Has modern medicine advanced significantly in the treatment of the body but not necessarily of the brain? What are the molecular explanations for the decline in brain health during the age of longevity? A full accounting of the roles of DHA in neurons requires balancing the enormous benefits of these molecules against the risks. Introducing the dual chemical personalities of DHA from an evolutionary perspective, Neurons and the DHA Principle explores DHA from the standpoint of benefita€“risk analysis, opening new perspectives for understanding how DHA functions in neurons.... Ames test (Marnett et al., 1985) and Fraga and colleagues (1991) showed that DNA of sperm seems to be a a€œhot spota€ for mutagenesis. ... The results of this analysis are discussed below with an eye toward understanding the role ... 13.1 RETINOBLASTOMA OCCURS IN A TISSUE WITH THE HIGHEST LEVELS OF DHA IN THE BODY In our initial literature search for any linkages between DHA and ... Children carrying one defective copy of the Rb gene are predisposed to cancer.

Title:Neurons and the DHA Principle
Author: Raymond C. Valentine, David L. Valentine
Publisher:CRC Press - 2012-10-26

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